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Common name:

Product name: uloric

Full names: febuxostat, febuxostat, feburic, febuxostat, uloric, zurig

Indications:

For the treatment of chronic hyperuricemia (gout). 

Usage and dosage:

Febuxostat was started at 10 mg/day for 2 weeks, then increased to 20 mg/day for 4 weeks, then to 40 mg/day. Starting with a low dose and gradually increasing the dose can prevent acute gout attacks caused by initial changes in blood uric acid levels. Treat with febuxostat 40 mg/day for 6 months, and check the uric acid level regularly. Generally, it takes 6 months to clean up excess blood uric acid in the body. 

After 6 months of treatment:

(1) If the serum uric acid level remains between 240 umol/l and 360 umol/l, maintain febuxostat 40 mg/day treatment.

(2) If the blood uric acid level is higher than 360 umol/l, increase the dose of fexostatin by 60 mg/day, up to a maximum of 80 mg/day, and monitor blood uric acid, liver and kidney function regularly.

(3) If the blood uric acid level is lower than 240 umol/l, the dose of febuxostat can be reduced to 20 mg/day and the treatment can be maintained for 6 months. Adverse reactions:

1. Liver function damage (unknown frequency), because the increase in AST (GOT) and ALT (GPT) is accompanied by liver function damage, patients should have regular examinations and discontinue medication if they are found to be unwell.

2. Allergy (unknown frequency), systemic rash, skin rash, etc. Patients should be checked regularly and discontinue medication if any discomfort is found. 

Other side effects

1. (Unknown frequency): Decreased platelet count, anemia;

2. (Less than 1%): Decreased number of white blood cells;

3. (less than 1%): TSH increase;

4. (Unknown frequency) Headache, abnormal taste;

5. (Less than 1%) Numbness in hands and feet, dizziness;

6. Rapid heartbeat;

7. (Less than 1%) Abnormal electrocardiogram;

8. (Less than 1%) Diarrhea, abdominal discomfort, nausea, and abdominal pain;

9. (1%-5%) Abnormal liver function test values [increased ALT (GPT), increased GOT (AST), increased γ-GTP, etc.);

10. (Unknown frequency) Urticaria;

11. (less than 1%) rash, pruritus, erythema;

12. (less than 1%) joint pain;

13. (1%-5%) Pain in the limbs, discomfort in the limbs, increased CK (CPK), and muscle pain;

14. (Unknown frequency) Decreased urine output;

15. (Less than 1%) Increase in β2 microglobulin in urine, increase in creatinine in blood, and increase in blood urea;

16. (Unknown frequency) Edema;

17. (Less than 1%) Feeling of fatigue, thirst, increased blood triglycerides, and increased CRP. 

Taboo:

1. Patients with past allergies to the essential ingredients;

2. Patients taking thiol-containing drugs or azathioprine tablets at the same time. 

Things to note:

Due to the rapid decrease in serum uric acid concentration in the early stage of taking this product, the uric acid deposited in the tissue can be mobilized, so symptoms similar to gout attacks may occur. In this case, nonsteroidal anti-inflammatory drugs or colchicine can be used for preventive administration. In addition, during the treatment of this product, some patients need to be monitored for symptoms related to myocardial infarction and liver damage. 

Storage:

Store in a cool place.