非布索坦治疗痛风效果怎么样？

Xanthine oxidase is a key enzyme that promotes the production of uric acid. Increased uric acid can cause gout, and it can reduce the level of uric acid in the blood of patients with hyperuricemic gout. So, what is the therapeutic effect of febuxostat in treating gout?

Clinical studies have shown that the therapeutic effect of Febuxostat is safe and effective. Febuxostat is metabolized by the liver and is not excreted by the kidneys. Therefore, there is no need to reduce the dose for patients with moderate or severe hepatic and renal insufficiency. The dosage is 40 mg or 80 mg once daily and is not recommended for the treatment of gout patients without hyperuricemia.

The effectiveness of febuxostat in the general population is about 70%, which is much higher than that of allopurinol. And compared to placebo, there was a clear difference. Clinical trial data on more than 3,000 people show that febuxostat can effectively reduce uric acid in the blood to 360 μmol/L after taking the drug for six months.

In gout patients with mild or moderate renal impairment, it can be seen that febuxostat still maintains a very high remission rate, significantly higher than allopurinol, and no dosage adjustment is required for patients with mild or moderate renal impairment, which means that febuxostat has basically no possibility of renal impairment.

Febuxostat is currently the best treatment for patients with moderate and especially severe kidney disease—at least, studies show it is safe and effective.

Febuxostat tablets are suitable for the long-term treatment of hyperuricemia in gout patients. Therefore, if gout patients develop hyperuricemia, they can be treated with the tablets for a long time, which will have a more prominent therapeutic effect. However, the dosage must be correct and standardized, and the medication period must be certain. You must strictly follow the doctor's instructions and do not use this drug indiscriminately. Although this drug has a relatively good therapeutic effect, if it is used excessively for a long time, it may cause some intolerable side effects. Therefore, patients must pay attention during use!