非布司他推荐使用的剂量多少呢？

At present, there are many kinds of drugs to treat gout, but none of them are as effective as the treatment of gout!

Gout occurs due to excessive production of uric acid in the body and reduced kidney clearance ability. Uric acid accumulates in the body, leading to the deposition of urate crystals in joints and various organs. Therefore, the usual treatment for gout is to promote uric acid excretion and inhibit uric acid production, and take appropriate measures to improve related symptoms.

The production of uric acid in the body is related to purine metabolism. In the final step of purine metabolism, hypoxanthine generates xanthine under the action of xanthine oxidoreductase (XOR), and then further generates uric acid. Inhibiting the activity of this enzyme can effectively reduce the production of uric acid.

Febuxostat is the latest XOR inhibitor developed in the world. It acts on this oxidase highly selectively, reducing the synthesis of uric acid in the body and lowering the concentration of uric acid, thereby effectively treating ventilation diseases.

So, what is the recommended dose of febuxostat for patients to treat gout?

The recommended dose of febuxostat starts at 10 mg/day for 2 weeks, then increased to 20 mg/day for 4 weeks, then to 40 mg/day.

Starting with a low dose and gradually increasing the dose can prevent acute gout attacks caused by initial changes in blood uric acid levels.

Treat with febuxostat 40 mg/day for 6 months, and check the uric acid level regularly. Generally, it takes 6 months to clean up excess blood uric acid in the body.

After taking it for about 6 weeks, test the uric acid value again to see if the uric acid value has dropped. If it has dropped, it means that this dose is effective for you. You can choose to increase the dose, or you can choose to maintain this dose and continue taking it.

The purpose of taking it is to take it until the uric acid value stabilizes between 330-360. At this time, you can reduce the dosage according to the doctor's advice. During the reduction period, you need to check the uric acid value every few weeks. After it stabilizes, you can take it every other day. After it has stabilized for a while, you can stop taking it.