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Febuxostat, transliterated as "", also called "Febuxostat", is a better drug for the treatment of gout. So, when will Febuxostat be launched on the market?

It was approved for marketing by European EMEA in October 2008, with the trade name "Adenuric".

In February 2009, the US FDA approved it for sale under the trade name "ULORIC".

In the 2012 American College of Rheumatology Gout Guidelines, febuxostat is recommended as a Class A recommendation for drug treatment of patients with hyperuricemia and gout, which is also the first-line drug choice.

In June 2013, China's State Food and Drug Administration approved febuxostat for marketing in China.

In addition, the goal of gout treatment is to reduce and maintain serum uric acid ≤6.0mg/dl. In addition to lifestyle changes, urate-lowering drugs are usually required to achieve this goal, and allopurinol is one of the most widely used drugs. Clinically, the application of allopurinol usually starts with a low dose (100 mg/d) and gradually increases the dose to achieve the target value of controlling blood uric acid. The maximum dose is 800 mg/d. There is currently no recommended dose.

However, it has been clinically found that in some patients, allopurinol alone cannot achieve the above target value of serum uric acid, and a higher dose or combined use of other uric acid-lowering drugs may be needed. 20% of patients may experience various adverse reactions, such as rash, hypersensitivity syndrome, fever, blood system damage, abnormal liver function, renal function damage, etc., of which 5% of patients cannot tolerate the adverse reactions. Especially for patients with unsatisfactory treatment effects, intolerance of adverse reactions, and patients with renal impairment, the wide clinical application of allopurinol is limited.

Febuxostat was first launched in the United States in March 2009 and is clinically used to treat hyperuricemia. The specificity of the inhibitory effect of febuxostat can avoid the possible adverse reactions of allopurinol drugs. Therefore, it has become the drug of choice for the treatment of gout!