非布司他是什么？

What is it? Febuxostat tablets are a new type of urate-lowering drug that is a selective xanthine oxidase inhibitor. It is suitable for the long-term treatment of hyperuricemia in patients with gout. Not recommended for use in asymptomatic hyperuricemia. There are no studies on the use of this product in patients with secondary hyperuricemia (including organ transplant recipients), so it is not recommended to use this product in patients with massively elevated urate levels (such as malignant diseases, Lesch-Nyhan syndrome). A few cases have shown that xanthine concentration in urine can be deposited in the urinary tract after a significant increase.

What are the advantages of febuxostat in treating gout:

1. Strong uric acid-lowering effect: The effect of one febuxostat tablet is about the same as that of three allopurinol tablets. The main reason is that its uric acid-lowering therapeutic effect is accurate and its uric acid-lowering speed is fast. It can often reach the target level of blood uric acid in 2-4 weeks. I often describe it as a "missile" for reducing uric acid. Personally, I think it is better than allopurinol and benzbromarone, and can reach the target level of blood uric acid faster and improve patient compliance. It causes less damage to renal function and is suitable for patients with mild to moderate renal impairment.

2. Fewer allergic reactions: Although drug rash may occur with febuxostat, it is significantly lower than that of allopurinol. The drug is safe and rarely fatal allergic reactions occur, so febuxostat may be the first choice for patients allergic to allopurinol.

3. Less renal damage: Through liver metabolism, patients with mild to moderate renal impairment do not need to adjust the drug dosage. Because it inhibits the production of uric acid from the beginning and does not increase the burden on the kidneys, patients with urinary tract stones can also use it with confidence. When using allopurinol, the dose must be adjusted according to the condition of the kidneys, so febuxostat is more suitable for patients with renal insufficiency and kidney stones.

4. Easier to use: Once a day, the uric acid-lowering effect can often be achieved, which can greatly improve the patient's medication compliance.

The above is the editor's introduction. I hope it can help patients and friends understand febuxostat more clearly.