雷洛昔芬的用药指南

Raloxifene is a selective estrogen receptor modulator (SERM) that plays an important role in the treatment of postmenopausal osteoporosis and the prevention of breast cancer. By targeting and modulating estrogen receptors, the drug produces estrogen-like protective effects in bone tissue while exerting an antagonistic effect in breast tissue. Patients should understand the standardized medication methods, identify contraindication groups, and understand medication precautions for special groups.

Raloxifene Medication Guide

The standard medication regimen of raloxifene must strictly follow the recommended dosage and auxiliary treatment requirements to maximize the therapeutic effect and reduce the risk of adverse reactions.

Standard dosage regimen

The recommended dose is 60mg, taken orally once a day, and the dosage time is not affected by meals. The tablet should be swallowed whole and avoid breaking or chewing. Continuous use can achieve the best bone protection effect.

Nutritional supplement recommendations

It is necessary to supplement 1500mg of elemental calcium every day, and the effect is better when taken in divided doses. The recommended dose of vitamin D is 400-800IU/day. Patients with advanced age or chronic diseases need to adjust the dose according to the blood 25-hydroxyvitamin D level.

Drug monitoring requirements

Assess thrombosis risk factors every 3 months in the early stage of treatment, and monitor liver function regularly. It is recommended to conduct bone density examinations every year to evaluate the effectiveness of treatment. If you have suspicious symptoms of thrombosis, you should seek medical attention immediately.

Standard use of raloxifene requires consideration of standard dosage, nutritional support and regular monitoring.

Contraindications of raloxifene

Raloxifene has clear restrictions on its use in specific groups. Identifying these contraindications is the key to preventing serious adverse events.

Absolute contraindications

Contraindicated for pregnant women, lactating women and women of childbearing potential. It is contraindicated in patients with active venous thromboembolism or those with a recent history of thrombosis. Not recommended for patients with severely impaired liver function.

Relative contraindications

Patients who are bedridden for a long time or after major surgery should postpone taking the drug. People at high risk of cardiovascular disease need to carefully evaluate the benefit-risk ratio. People with a history of gallbladder disease may have worsened symptoms.

Drug incompatibility

It is prohibited to use it in combination with cholestyramine. Avoid use during systemic estrogen therapy. Coagulation function must be closely monitored when combined with anticoagulants such as warfarin.

Strictly controlling the range of contraindications for raloxifene can effectively avoid serious adverse events and ensure medication safety.

Raloxifene medication for special groups

Patients with different physiological states and organ dysfunction need to adopt individualized medication strategies when using raloxifene.

Usage in elderly patients

Patients over 65 years old do not need to adjust the dosage, but they need to strengthen blood clot monitoring. It is recommended to evaluate liver and kidney function every 6 months and increase the dose of vitamin D supplementation appropriately.

Patients with hepatic and renal insufficiency

Patients with mild hepatic impairment should use reduced dosage. Patients with moderate to severe hepatic and renal insufficiency should use it with caution. It is recommended that the starting dose be halved and relevant indicators should be closely monitored.

Patients who plan to have surgery need to stop taking the drug 4 weeks in advance. Raloxifene treatment can only be restarted after the patient has fully recovered their ability to move after surgery and is confirmed to have no risk of thrombosis.