雷洛昔芬(Evista)原研药的正规购买方式

Raloxifene (Evista), a classic drug for the treatment of postmenopausal osteoporosis, increases bone density and reduces the risk of breast cancer by selectively regulating estrogen receptors. This drug has been on the market in mainland China for many years and is included in the Class B National Medical Insurance List. Patients can obtain the original drug from Eli Lilly in the United States through the following formal channels.

Regular purchase methods of Raloxifene (Evista) original drug

Purchase channels

Regular public hospitals can purchase it with a doctor’s prescription, and the medical insurance reimbursement price is determined according to local conditions. Some formal online platforms support prescription uploading and will be shipped after review by a pharmacist. It is recommended to choose a platform with formal qualifications to purchase.

Are generic drugs effective?

Generic drugs use the same active ingredients as the original drugs, and have also undergone strict approval and inspection. The content and quality of their active ingredients are basically the same as the original drugs, and the therapeutic effects are similar to the original drugs.

Which drugs will Raloxifene (Evista) interact with?

The combination of this drug with some drugs may affect the efficacy or increase the risk. Special attention is required:

Drugs that are prohibited from being used in combination

Cholestyramine can reduce the blood concentration of raloxifene by 60%, and it needs to be taken at least 4 hours apart. Systemic estrogen preparations will increase the risk of thrombosis, and estrogen therapy needs to be restarted after 3 months of discontinuation.

Drugs requiring dose adjustment

Raloxifene may prolong prothrombin time, and the INR value needs to be monitored weekly (target 2.0-3.0) when combined with warfarin. Drugs with high protein binding rates, such as diazepam and lidocaine, may competitively bind to plasma proteins. It is recommended to reduce the dose by 25% and monitor for adverse reactions.

No interaction with bisphosphonates has been found. Please consult a professional doctor for specific medication.

Precautions for raloxifene (Evista)

Standardized medication is the key to treatment. Please focus on the following matters:

Thrombus risk prevention and control

The risk of venous thrombosis is highest in the 4 months before treatment. Avoid sitting for more than 2 hours. Move your ankle joints every 45 minutes when flying. Measure the circumference of both calves every morning. When unilateral leg swelling, chest pain or difficulty breathing occur, lie down immediately and seek emergency treatment.

Special Scenario Treatment

Stop medication 72 hours before planned surgery. Medication should be suspended during acute diarrhea and restarted 24 hours after symptoms disappear. After receiving an iodine-containing contrast agent examination (such as enhanced CT), you need to observe for 72 hours before taking medicine. Avoid high-temperature saunas (>40℃) or extremely cold environments (<-10℃) during treatment.

Long-term monitoring requirements

Bone density should be tested every 3 months during initial treatment, and once a year after stabilization. Review liver function (ALT/AST) and coagulation function (D-dimer) every 6 months. Annual gynecological ultrasound + mammography examination. Abnormal uterine bleeding (lasting >3 days) requires immediate medical attention.

The storage conditions of medicines are that the original packaging is placed in a dry and light-proof environment at 20-25°C, and brief exposure to 15-30°C is allowed. After unpacking, keep the tablets in the aluminum foil plate to avoid moisture.