唑来膦酸注射液的作用效果与价格？

It can effectively improve the bone turnover index level of patients after hip replacement, inhibit bone absorption and reduce bone mass around the prosthesis, increase bone density around the prosthesis, delay postoperative prosthesis subsidence, and improve patients' hip joint function.

It is understood that the zoledronic acid specification of India Natco is 4mg, and the reference price range is between 90 and 100.

About Zoledronic Acid Injection

Zoledronic Acid Injection (100ml: 4mg) is a bisphosphonate drug developed by Novartis. It was first approved in the European Union in 2001 and was subsequently approved for marketing in the United States and Japan. It is used to treat hypercalcemia caused by malignant tumors, and is used in combination with standard anti-tumor drugs to treat bone damage in patients with solid tumor bone metastasis and multiple myeloma.

The role of zoledronic acid injection

Zoledronic acid is a third-generation bisphosphonic acid drug, mainly used to treat bone metabolic diseases such as osteoporosis. Zoledronic acid has high bioavailability after intravenous infusion. The drug will be slowly released into the blood and can maintain effective blood concentration for a long time. Its main pharmacological effect is to inhibit bone resorption.

The currently accepted view is that zoledronic acid works through the following aspects:

1. Inhibiting osteoclast activity: Zoledronic acid can interfere with the function and activity of osteoclasts, reduce their adsorption and degradation of bone tissue, thereby inhibiting bone resorption.

2. Inducing osteoclast apoptosis: Studies have shown that zoledronic acid can induce osteoclast apoptosis, thereby reducing the number and activity of osteoclasts and reducing bone resorption.

3. Activate osteoblasts: Zoledronic acid can also stimulate the activity of osteoblasts and promote the bone formation process, thus balancing bone metabolism and reducing the occurrence of diseases such as osteoporosis.

It should be noted that the use of zoledronic acid should be under the guidance of a doctor and strictly follow the dosage and duration of medication. In addition, zoledronic acid may also produce some side effects, such as gastrointestinal discomfort, myalgia, etc. Therefore, patients' reactions and occurrence of adverse events should be paid close attention to during use.

For more information on the functions of zoledronic acid injection, please refer to: This article also explains in detail the functions and efficacy of zoledronic acid injection.

Effects of Zoledronic Acid Injection

Research purpose: To observe the effect of Zoledronic Acid Injection in the treatment of osteoporosis in type 2 diabetes [1].

Research method: 60 patients with type 2 diabetes and osteoporosis admitted to Boai Hospital in Longyan City, Fujian Province were selected and divided into a research group and a control group according to the random number table method, with 30 cases in each group. The control group received routine supplementation of calcium + vitamin D preparations, while the research group received zoledronic acid injection on the basis of the control group. Both groups were treated for 1 year. Compare the clinical efficacy, changes in bone density levels and bone metabolism-related indicators between the two groups before and after treatment.

Research results: The total effective rate of treatment in the research group was 93.33%, which was higher than the 40.00% in the control group (χ2= 19.200, P<0.001); after 1 year of treatment, the bone density levels of the L2~4 femoral neck and the inner side of the greater trochanter in both groups were higher than before treatment, and the study group was higher than that of the control group (all P<0.01); after 1 year of treatment, the levels of BALP, BGP, and TRACP5b in both groups were lower than before treatment, and the study group was lower than those of the control group (all P<0.01).

Research conclusion: The addition of zoledronic acid injection to conventional treatment has significant efficacy in the treatment of type 2 diabetes combined with osteoporosis. It can effectively improve patients’ pain symptoms, significantly increase bone density, and reduce the risk of fragility fractures. The patients have good compliance, and the clinical medication is safe and effective, and is worthy of clinical promotion.

However, the specific efficacy and side effects of zoledronic acid injection still need to be evaluated based on the patient's specific situation and the guidance of the doctor. When using zoledronic acid injection, you should follow your doctor's advice and pay attention to possible side effects, such as musculoskeletal pain, gastrointestinal discomfort, etc.

The price of zoledronic acid injection

It is understood that the zoledronic acid specification of India Natco is 4mg, and the reference price range is between 90 and 100.

In China, zoledronic acid injection has been launched and has been included in the national medical insurance. Patients can purchase it directly from domestic pharmacies and hospitals with prescriptions. However, more people choose to trust overseas medical service agencies to help them purchase more affordable zoledronic acid, which is more suitable for patients to use for a long time.

References

[1] Xu Yuebo, Liu Cailing, Lan Qifang, etc. The effect of zoledronic acid injection in the treatment of type 2 diabetes osteoporosis [J]. Clinical Rational Drug Use, 2023, 1 6(16):72-74.DOI:10.15887/j.cnki.13-1389/r.2023.16.020

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