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immunotherapy

Fayuvi (rebisufligene etisparvovec-hopf) for MPS IIIA: AAV9 Single Infusion, Weight-Based Dose, Steroids, Liver/Platelet Monitoring

2026-09-20 04:31:29

Fayuvi is an AAV9, one-time intravenous gene therapy that delivers functional SGSH for pediatric MPS IIIA with preserved neurodevelopment. Use 3.0×10¹³ vg/kg, start glucocorticoids one day before infusion, infuse over about one hour, and monitor liver enzymes, coagulation, platelets, anti-AAV9 antibodies, and long-term safety.

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ASCO 2026: Spevatamig Opens a New Path in Pancreatic Cancer Immunotherapy

2026-08-10 07:19:45

At the 62nd ASCO Annual Meeting, targeted therapies, ADCs and immunotherapies advanced on three fronts against pancreatic cancer. Phanes Therapeutics' CLDN18.2/CD47 bispecific antibody spevatamig, combined with GnP chemotherapy, showed striking first-line data in metastatic pancreatic cancer, and its innate immunity–enhancing mechanism may break the "cold tumor" dilemma.

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