Olipudase alfa-rpcp price and purchase channels

Olipadase is not yet on the market in China, which poses a big problem to patients in need. Patients cannot purchase this product directly in the country, but they can purchase it through formal overseas channels. Overseas, the cost of one 4 mg Olipadase powder injection for intravenous injection is approximately US$1,628.

Olipadase is an enzyme replacement therapy drug used to treat a rare genetic disease - chronic non-neuronal acidic sphingolipidosis (ASMD) in adults and children (ASMD, also known as Niemann-Pick disease type B).

The active ingredient of olipudase alfa is a recombinant human acid sphingolipidase, which is administered by intravenous infusion. Its main function is to replace the missing or insufficient ASM enzyme in the patient's body, promote the catabolism of sphingolipids in the body, thereby reducing the abnormal deposition of sphingolipids in tissues and organs, improving organ function, and alleviating clinical symptoms.
Olipadase is suitable for use in well-diagnosed adult and pediatric patients with chronic non-neuronal acidic sphingolipidosis, especially those showing symptoms such as splenomegaly, hepatomegaly and abnormal lung function.
Olipadase has shown significant efficacy in multiple clinical trials. Studies have shown that after continued treatment, the patient's spleen and liver volumes were significantly reduced, lung function was improved, and blood biochemical indicators tended to be normal. In addition, the patient's quality of life and mobility have also been significantly improved. The safety and tolerability of the treatment are generally good. Common adverse reactions include infusion-related reactions, such as fever, chills, headache, etc. Most of them are mild to moderate and can be controlled after symptomatic treatment or dose adjustment.
Reference: https://www.xenpozyme.com/