What is the specific mechanism of action of Ivosidenib?

Ivosidenib (Ivosidenib) is an anti-isocitrate dehydrogenase 1 mutation (IDH1 mutation ) targeted therapy drugs are mainly used to treat malignant tumors such as acute myeloid leukemia (AML) carrying IDH1 gene mutations. IDH1Mutation can lead to abnormal cell metabolism, thereby promoting the occurrence and development of tumors. The emergence of ivonib provides a new treatment idea for this type of mutant cancer and has strong potential for precision treatment.

Under normal circumstances, IDH1enzyme is responsible for converting isocitrate into α-ketoglutarate, while the mutated IDH1 will abnormally produce a metabolite called "2-hydroxyglutarate" (2-HG). 2-HG can interfere with the intracellular DNA and histone methylation processes, hinder the differentiation of hematopoietic stem cells, and promote the abnormal proliferation of leukemia cells. Ivonib inhibits the activity of mutant IDH1, effectively reduces the level of 2-HG and restores the normal differentiation function of cells.

Research shows that while reducing 2-HG levels, ivonib can also induce leukemia cells to differentiate into normal hematopoietic cells, rather than directly killing cancer cells. The idea of u200bu200bu200bu200bthis "differentiation therapy" is different from traditional chemotherapy. It is gentler and has fewer side effects. It is especially suitable for elderly or weak AML patients. In addition, the drug is also being explored for cholangiocarcinoma, glioma and other IDH1 mutation-related tumors.

In general, the mechanism of action of ivonib is to accurately identify and inhibit the metabolic disorders caused by IDH1 gene mutations, thereby breaking the "metabolic driving factors" of tumor development and restoring the normal functions of cells. This mechanism not only improves the targeting of treatment, but also represents the development direction of modern molecular targeted therapy, bringing tangible survival benefits to patients related to IDH1 mutations.

Reference: https://go.drugbank.com/drugs/