What are the possible adverse reactions of Niraparib Abiraterone Tablets?

Niraparib Abiraterone Tablets (Akeega) is a compound targeted drug, and its adverse reactions are mainly closely related to the pharmacological mechanisms of its two active ingredients, niraparib and abiraterone. Niraparib is a PARP inhibitor that mainly achieves anti-cancer effects by inhibiting the DNA repair function of tumor cells; while abiraterone blocks the synthesis of androgens by inhibiting the CYP17 enzyme. Although the two mechanisms work together to improve the therapeutic effect, they may also bring about a series of systemic side effects, which require close attention during the treatment process.

Common adverse reactions of Akeega include hypertension, fatigue, nausea, joint or muscle pain, hypokalemia, edema, and elevated liver enzymes. Among them, the adverse reactions related to mineralocorticoids caused by abiraterone, such as hypertension, hypokalemia and fluid retention, are more typical, so prednisone is usually combined with prednisone during treatment to counteract its effects. The components of niraparib may cause side effects related to the hematopoietic system, such as anemia, neutropenia, and thrombocytopenia. Most of these reactions are dose-dependent, and regular blood routine examinations are required to monitor safety.

In addition, some patients may experience gastrointestinal discomfort, such as nausea, abdominal pain or loss of appetite, as well as non-specific neurological reactions such as fatigue and insomnia during treatment. Of note, long-term use of niraparib may slightly increase the risk of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML), although such serious reactions are rare.

Abnormal liver function is also one of the side effects that needs attention. Abiraterone can affect liver enzyme metabolism, especially in patients with underlying liver disease. Liver function should be checked regularly to determine whether the dose needs to be adjusted or treatment suspended. In clinical practice, Although Akeega has shown good efficacy, doctors need to individually adjust the dosage, assess risks and actively deal with adverse reactions during the medication process to achieve the best treatment balance.

Reference materials:https://www.drugs.com/akeega.html