How much does a box of Ruitusepatinib/Selpatinib capsules cost?

Selpercatinib, also known as selpercatinib (Selpercatinib), is a targeted therapy drug targeting RET gene fusion mutations. It is suitable for patients with non-small cell lung cancer, thyroid cancer, etc. Currently, the original version of the drug has been launched in China, but as of 2025, it has not yet been included in the national medical insurance directory. Patients still need to purchase it at their own expense, so they may face greater financial pressure.

Taking the specifications of 80mg*56 tablets currently on the market as an example, the selling price of domestic original drugs usually exceeds RMB 10,000. Since it is not covered by medical insurance, the entire cost of the drug must be borne by the patient. If it needs to be taken for a long time, the financial burden will be significant. In addition, since medication needs to be continuously adjusted according to the condition, the actual expenditure may far exceed the price of a single box. Patients should fully communicate with their doctors before use to understand the course of treatment and estimated total cost.

In overseas markets, Selpercatinib’s original drug is more expensive, with common price ranges ranging from 20,000 yuan to more than 100,000 yuan. The specific amount is greatly affected by the brand, sales country and exchange rate fluctuations. Some countries may provide higher specifications and larger packages, but the overall price is still not low, which is a heavy burden for most ordinary families.

In order to alleviate the financial pressure on patients, some overseas pharmaceutical manufacturers have launched more affordable generic versions. For example, the generic drug produced in Laos (40mg*120 capsules) sells for about more than 2,000 yuan. Its active ingredients are basically the same as the original drug and can be used as one of the treatment options. However, when purchasing generic drugs, you need to pay attention to the legal compliance of the channels and use them under the guidance of a doctor to ensure the therapeutic effect and drug safety.

Reference materials:https://en.wikipedia.org/wiki/Selpercatinib