How many pills of lorlatinib/lorlatinib should be taken daily

Lorlatinib/lorlatinib ( Lorlatinib) is an oral targeted drug with a standard dose of 100 mg per day, and this dose is usually achieved in the form of a single-strength tablet. Currently, the common dosage form of the original brand drug on the market is 100 mg film-coated tablets. That is to say, most patients only need to take one 100 mg lorlatinib tablet per day in the standard treatment plan, without the need to take divided doses or the total dose of multiple tablets.

Lorlatinib tablets are film-coated and designed to be taken in full at one time. This tablet should not be chewed, crushed or broken, as this form of damage may affect its pharmacokinetic properties, leading to unstable drug absorption, affecting efficacy and even inducing side effects. In addition, if the patient needs to adjust the dose due to side effects or tolerance issues, the doctor may adjust it to 75 mg or 50 mg once daily. In this case, patients should use other dosage forms provided by the manufacturer, such as 75 mg tablets or 50 mg tablets, rather than splitting the 100 mg tablet.

If patients mistakenly take multiple pills while taking the medicine, they should report it to the doctor immediately and observe whether serious side effects occur, such as cognitive disorders, high cholesterol, hallucinations, or mood swings. On the contrary, if you miss a dose, you should take it as soon as possible within 12 hours after you remember it. If it is close to the time of the next dose, you should skip the missed dose and avoid taking a double dose.

Larlatinib is metabolized by the CYP3A4 enzyme in the body and interacts with many commonly used drugs. Therefore, it needs to be evaluated and guided by a professional doctor when used in combination with other drugs. In particular, concomitant use with strong CYP3A4 inducers should be avoided to avoid reducing the concentration of lorlatinib in the body and thus affecting the therapeutic effect. If patients need to take other chronic disease drugs for a long time, a comprehensive medication evaluation should be conducted before taking lorlatinib for the first time.

References：https://www.lorbrena.com/