What is the expected market price of lorlatinib/lorlatinib in 2025?

Lorlatinib/Lorlatinib is a targeted drug used to treat advanced non-small cell lung cancer (NSCLC). It is especially suitable for patients who have received other ALK inhibitor treatments and have progressed. Its mechanism of action prevents the growth and spread of tumor cells by inhibiting multiple tumor-related signaling pathways such as ALK (anaplastic lymphoma kinase) and ROS1 (homologous rearrangement of salivary gland tumor gene 1). In recent years, with the development of precision medicine, lorlatinib, as a new targeted drug, has gradually received widespread clinical attention at home and abroad.

Currently in China, the original drug of lorlatinib is called lorlatinib tablets, and has been successfully included in Class B medical insurance reimbursement, which greatly facilitates patients’ purchase and use. Common packaging specifications include 90 tablets of 25mg and 30 tablets of 100mg. The market price is generally around 20,000 yuan. However, the market price of original drugs is usually between RMB 30,000 and RMB 50,000, which to a certain extent reflects the high cost of R&D and production of new drugs as well as the relationship between market supply and demand. In comparison, the price of original drugs in countries such as Türkiye is relatively low, about 10,000 yuan, providing more choices for some patients with limited financial conditions.

In addition to original drugs, some lower-priced generic drugs have also appeared on the market. These generic drugs are basically the same as the original drugs in terms of ingredients and efficacy, and can meet the needs of some patients. For example, a generic drug of 100mg*30 tablets produced by a pharmaceutical factory in Laos costs about RMB 1,000, which greatly reduces the financial burden on patients. However, it should be noted that although generic drugs are affordable, they still need to be carefully selected in terms of quality and efficacy to ensure that patients receive safe and effective treatment.

Reference materials：https://www.lorbrena.com/