Who is suitable for Fezonatan? Contraindications to note

Fezolinetant is a new treatment for vasomotor symptoms of menopause, especially for postmenopausal women with moderate to severe hot flashes that affect their quality of life. The biggest feature of this drug is its non-hormonal nature, which makes it especially suitable for patients who have contraindications or concerns about hormone replacement therapy. It interferes with the hypothalamic heat regulation center by antagonizing neurokinin 3 (NK3) receptors, thereby reducing the frequency and severity of hot flashes. It is a unique choice among many current menopausal drugs with a unique mechanism.

Fezonatant is particularly suitable for women who cannot tolerate traditional estrogen replacement therapy or have a history of estrogen contraindications such as breast cancer and thrombotic diseases. For patients who want to avoid the side effects of hormonal drugs but urgently need to control menopausal-related symptoms, filazonatant provides a safer alternative. However, this drug does not work for everyone. First of all, for patients with moderate to severe liver dysfunction, since fezonatant is eliminated by liver metabolism, its blood concentration can significantly increase, which may increase drug-related hepatotoxicity. Therefore, these people are usually classified as contraindications for use. Secondly, there is insufficient evidence that this drug can be safely used in pre-menopausal women, or in patients with severe cardiovascular disease or renal insufficiency. Therefore, these people need to use it with caution or even avoid it.

In addition, fezonatant is not suitable for women who are pregnant or breastfeeding. Although menopausal women are generally no longer of childbearing age, misuse should be avoided in individual women in the perimenopausal stage. In addition, if the patient has a known history of allergy to fezonatant or its excipients before taking the drug, it should also be listed as a contraindication. Clinicians should obtain a detailed understanding of the patient's medical history, concomitant medications, and liver and kidney function status before evaluating the use of fezonatant to ensure drug safety.

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