Will using fezonatant affect the menstrual cycle?

Fezolinetant is mainly used to treat vasomotor symptoms in menopausal women. Its mechanism of action is to centrally block neurokinin 3 receptors (NK3R). It does not directly participate in the regulation of ovarian function, nor does it affect the secretion levels of luteinizing hormone (LH) or follicle-stimulating hormone (FSH). Therefore, from a theoretical perspective, fezonatant does not interfere with the normal progression of the menstrual cycle or accelerate its termination. However, it is worth noting that most of the users of this drug are women who are already in the perimenopausal or complete menopausal stage. This group of people itself is accompanied by natural phenomena such as irregular menstruation, prolonged cycles or amenorrhea. Therefore, changes in menstrual patterns during medication are not necessarily entirely attributed to the drug itself.

Some clinical observational studies have found that a very small number of patients in the menopausal transition period may experience mild early or late menstruation. This is often related to individual hormone fluctuations and lifestyle habits rather than direct drug effects. The non-hormonal nature of filazonatant determines that in addition to its thermoregulatory effect, it will not cause endometrial hyperplasia and will not induce ovulation. Therefore, for patients who are not yet completely menopausal but are experiencing symptoms such as significant hot flashes, filzonetam is a relatively mild, low-disruption medication option.

Overall, the pathway of action of fizonitant in women is highly differentiated from the menstrual regulatory mechanisms, making it a safe treatment option. In clinical use, doctors usually conduct a baseline assessment of the patient's menstrual status. If the patient still has regular menstruation, close observation of cycle changes in the early stages of medication can help determine whether there are changes in other physiological factors. If a patient has an obvious cycle disorder, it is recommended to check the hormone level and rule out other causes before determining whether it is related to non-zonetam. Most users experience significant benefits in relieving hot flash symptoms without disturbing their normal menstrual status.

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