How much does one month of evantumumab treatment cost approximately?

Amivantamab is a new bispecific antibody-targeted drug, trade name Rybrevant, used to treat patients with EGFR Exon 20 insertion mutation non-small cell lung cancer (NSCLC). The cost of one month of evantumumab treatment varies depending on body weight and medication regimen. Taking the current overseas original drugs as an example, the single price of the European version of the drug may be around 20,000 yuan, and the specific amount will be adjusted due to exchange rate changes.

In the combined treatment plan, when the patient weighs less than80 kg, 1,400 mg is injected intravenously every week for a total of 4 times in the first 4 weeks, and 1,750 mg is injected every three weeks starting from the 7th week; while for patients weighing 80 kg or more, 1,750 mg is injected weekly for a total of 4 times, and 2,100 mg is injected every three weeks starting from the 7th week. Based on overseas market price estimates, a single dose of medicine costs about 20,000 yuan. A total of 4 times of medication are required in the previous month. The total dose is high, and the treatment cost may be around 80,000 yuan.

If the evantumumab single-agent regimen is adopted, patients weighing less than 80 kg will receive 1050 mg per week for a total of 5 times in the first 5 weeks, and 1050 mg will be injected every three weeks starting from the 7th week; those weighing 80 kg or more will receive 1400 mg per week for a total of 5 times, and then 1400 mg will be injected every three weeks. In this case, the cost of one month's treatment also depends on the dose, and the estimated total cost may also be between RMB 60,000 and RMB 80,000.

It is worth noting that evantumumab has not yet been commercially sold on a large scale in mainland China and has not yet been included in the medical insurance catalog. Therefore, if patients purchase the drug through overseas channels, they need to bear high drug costs at their own expense. At present, some cross-border drug service platforms can provide legal and compliant original drug procurement services. It is recommended that patients obtain drugs under the guidance of doctors and through formal channels.

Reference materials:https://www.rybrevant.com/