What is the price list of Pimoteb in Japan?

Pimitespib is a new type of HSP90 inhibitor developed in Japan. It is mainly used to treat advanced gastrointestinal stromal tumors (GIST) that have failed multiple lines of treatment. Such patients often have developed resistance to first- to third-line tyrosine kinase inhibitors such as imatinib, sunitinib, and regorafenib, and their treatment options are extremely limited. The launch of Pimitespib fills this clinical gap and provides new mechanistic targets and treatment directions, especially when tumors continue to progress. It inhibits heat shock protein 90 (HSP90) and promotes the degradation of oncogenic proteins such as KIT, thereby achieving tumor control. Clinical studies have shown that it has significant efficacy in extending progression-free survival.

Currently, pimetibib has not been approved for marketing in mainland China, so domestic patients cannot obtain the drug directly in hospitals or pharmacies. For patients with real clinical needs, the main way to obtain the drug is through legal overseas drug purchase channels, such as certified international drug purchasing agents or cross-border medical service institutions. It should be noted that patients should be under the guidance of a professional doctor when using overseas drugs to avoid adverse consequences caused by improper dosage or drug interactions.

In Japan, pimetibib is the Japanese version of the original drug, with the trade nameJeselhy, produced by Taiho Pharmaceutical Company. The drug specification is 40 mg per tablet, and one box contains 40 tablets. According to the recommended standard dose of 160mg per day, each box of medicine can be used for one week. The current price in the Japanese market is approximately more than RMB 10,000 (subject to exchange rate fluctuations and channel differences). Since this drug is a new type of targeted drug and there is no generic version yet, the price is relatively high. At present, there is no generic drug (generic drug) of Pimetibi on the global market, which also limits the room for price reduction to a certain extent.

Reference materials:https://en.wikipedia.org/wiki/Pimitespib