Can aprexitentan be purchased in China? Latest marketing progress and drug purchase channels

Aprocitentan, as a new type of antihypertensive drug, is mainly used to treat patients with hypertension whose blood pressure cannot be controlled by conventional drugs. It achieves antihypertensive effects by selectively antagonizing endothelinA receptors, dilating blood vessels and reducing vasoconstriction. Aprecitentan is considered important in patients with refractory hypertension, particularly as a combination therapy option when other antihypertensive drugs fail to adequately control blood pressure.

However, aprexitentan is not currently available in mainland China, so if patients need to use the drug, they usually need to purchase it from overseas through relevant channels. In the overseas market, the original drug Aprexitentan is sold in many countries, especially in the United States, Europe and other regions. The original version of aprecitentan is usually sold in the format of 12.5mg*30 tablets, and each box sells for about US$800. The price will vary due to factors such as exchange rate fluctuations and import taxes. For domestic patients, the price is relatively high, especially for patients who require long-term treatment. The cost of drugs may become a considerable burden.

For patients who want a more economical option, some generic versions of aprecitentan have been approved and entered the market in countries such as Laos. Laos's generic aprecitentan drug is consistent with the original drug in terms of specifications and dosage.The price of each box of 12.5mg*30 tablets is about RMB 600. Because generic drugs cost less to produce, they sell for much less than brand-name drugs, making them affordable for some patients.

Although aprexitentan is not yet on the market in China, as the State Food and Drug Administration continues to improve its review policy for generic drugs, it is not ruled out that the drug will gradually enter the Chinese market in the future. For patients in urgent need of treatment, they still need to purchase through overseas channels or wait for generic drugs to enter the Chinese market. Regardless of whether they choose the original drug or a generic drug, patients should follow their doctor's instructions when using aprecitentan to ensure safe use of the drug and maximize its efficacy.

Reference materials:https://go.drugbank.com/drugs/DB15059