Detailed explanation of the usage and dosage of Apremilast/Apremilast tablets, scientific medication is guaranteed!

Apremilast (Apremilast) is an oral small molecule targeted drug for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis (PSA). Its standard maintenance dose is 30 mg twice a day. The medication time can be arranged flexibly and is not affected by meals. Considering that some patients will experience gastrointestinal reactions, such as nausea, diarrhea or loss of appetite, in the early stages of medication, it is clinically recommended to start treatment by gradually increasing the dosage to improve drug tolerance. The specific recommended dosage plan is as follows:

On the first dayTake 10mg in the morning on the first day; 10mg in the morning and 10mg in the evening on the second day; 10mg in the morning and 20mg in the evening on the third day; 20mg in the morning and 20mg in the evening on the fourth day; 20mg in the morning and 30mg in the evening on the fifth day; starting from the 6th day, enter the maintenance dose, 30mg in the morning and evening every day. This dosage-increasing strategy has been proven in multiple clinical studies around the world to be effective in reducing early discontinuation rates and improving patient compliance. For patients with severe liver damage, due to reduced drug metabolism, it is recommended to reduce the dosage to 30 mg once a day to reduce possible adverse reactions caused by drug accumulation in the body.

In addition, apremilast is a non-immunosuppressive drug and does not require regular monitoring of laboratory indicators such as blood routine and liver and kidney function. However, in clinical practice, individual differences such as weight changes and mood changes still need to be observed. Drug metabolism mainly occurs through the liver and kidneys. Therefore, during use, you should avoid taking it with strong CYP3A4 inducers (such as rifampicin and carbamazepine) to avoid reducing its plasma concentration and efficacy. In summary, Apremilast should be administered step by step, paying attention to individual responses, and scientific dosage increase and maintenance dosage strategies are the core to ensure successful treatment and control of side effects.

Reference materials:https://go.drugbank.com/drugs/DB05676