What are the side effects of long-term use of Bitovil/Bikonprenol tablets? How patients respond scientifically

Biktarvy As a new generation of once-daily HIV compound antiviral drugs, it is well tolerated and has a relatively low incidence of side effects. However, during long-term use, some potential adverse reactions still need to be paid attention to. According to overseas post-marketing data and clinical trials (such as the GS-US-380 series of studies), its common side effects include mild headache, nausea, diarrhea, insomnia and fatigue. These symptoms usually appear in the early stages of treatment and gradually ease as the body adapts to the drug.

The integrase inhibitory mechanism of bictegravir sodium has fewer neuropsychiatric side effects than other similar drugs (such as dolutegravir), but anxiety, mood swings or sleep disorders may still occur in individual patients. If symptoms continue to affect your quality of life, you should discuss with your doctor whether it is necessary to change to another drug combination. Emtricitabine and tenofovir alafenamide fumarate (TAF) may be associated with mild changes in renal function and decrease in bone density, but the impact of TAF on the kidneys and bones is much less than that of early TDF (tenofovir disoproxil disoproxil), so it performs better in terms of long-term safety.

In addition, long-term medication also requires monitoring of liver function and blood lipid changes, especially in patients with a history of chronic hepatitis B or metabolic syndrome. It is worth emphasizing that TAF in Bituvit has an inhibitory effect on hepatitis B virus, but if the drug is stopped improperly, it may cause hepatitis B to rebound. Therefore, if there is hepatitis B infection, the treatment plan needs to be carefully evaluated.

In order to scientifically deal with side effects, patients are recommended to undergo regular laboratory tests, including liver and kidney function, electrolytes, viral load andCD4 cell count. Regular diet, moderate exercise, maintaining mental health, and timely reporting of adverse reactions are also crucial to long-term treatment.

Reference materials:https://www.biktarvy.com/