List of detailed instructions for cartegravir sodium tablets

Cabotegravir sodium tablets (cabotegravir), as an HIV-1 integrase strand transfer inhibitor (INSTI), plays an important role in the field of anti-HIV treatment. In combination with rilpivirine, it provides a new option for the short-term treatment of HIV-1 infection in adults and adolescents aged 12 years and older weighing at least 35 kg. This treatment regimen is particularly suitable for patients with stable virologic suppression (HIV-1 RNA<50copies/mL), no history of treatment failure, and no known or suspected resistance to cabotegravir or rilpivirine.

Categravir Sodium Tablets are also suitable for short-term pre-exposure prophylaxis (PrEP), which is designed to reduce the risk of HIV-1 infection through sexual intercourse. However, before starting PrEP with castegravir sodium tablets, the individual must be tested for HIV-1 and confirm that the result is negative, which is an important step to ensure the safety of the medication.

The mechanism of action of Cartegravir Sodium Tablets is to reduce the amount of HIV in the blood. Although it cannot completely cure HIV, it significantly reduces the patient's risk of acquired immunodeficiency syndrome (AIDS) and HIV related diseases (such as serious infections or cancer). At the same time, combined with safe sex and other lifestyle changes, the risk of HIV being transmitted to others can be further reduced.

In terms of usage and dosage, for the treatment of HIV-1 infection, canegravir sodium tablets are usually taken together with rilpivirine, once a day, 30 mgcantegravir sodium tablets with 25 mgrilpivirine, taken with food, and try to take them at the same time every day. This treatment regimen lasts 1 month (at least 28 days), and the last oral dose should be taken on the same day as the initial injection of Cabenuva. For the prevention of HIV-1 infection, the dose of castegravir sodium tablets is 30 mg once a day, also taken with food.

If you forget to take canegravir sodium tablets, you should take them as soon as possible as soon as you remember, but you still need to take them with meals. However, if it is close to the time for the next dose, the missed dose should be skipped and continue with the regular dosing schedule. Remember, do not take a double dose to make up for a missed dose to avoid unnecessary burden on the body.

Common side effects of cartegravir sodium tablets include headache, nausea, anxiety, abnormal dreams, difficulty falling asleep, etc. Serious side effects may include depression or mood changes (even suicidal thoughts or intentions), rash, fever, extreme fatigue, etc. Once these symptoms occur, patients should seek medical attention immediately and seek professional help.

Before taking canegravir sodium tablets, patients need to inform their doctor about all medications they are currently taking or plan to take, including prescription drugs, over-the-counter drugs, vitamins, nutritional supplements, and herbal products. You should also consult your doctor if you need to start, stop, or change any medicine while taking it. It is important to note that if you are taking antacids containing calcium, magnesium or aluminum, you should take them 2 hours before or 4 hours after taking castegravir sodium tablets to avoid drug interactions.

In addition, patients should specifically inform their doctor if they have or have had depression, other mental illness, or liver disease. For female patients, if they are pregnant, preparing for pregnancy, or breastfeeding, they should also inform their doctor in time. Because canegravir sodium tablets may have effects on the fetus or infant, patients infected with HIV or taking canegravir sodium tablets should not breastfeed.

Finally, regarding the marketing status of cartegravir sodium tablets, the drug was approved by the U.S. Food and Drug Administration (FDAFDA on January 21, 2021 span>) has been approved for official launch, with the trade name of Vocabria; it will be officially launched in my country in July 2023, with the trade name of Wankairui. Currently, there is no generic version of canegravir sodium tablets on the market. The price of the European version of the original drug is about RMB 8,000, and it has not yet been included in medical insurance. Patients with medication needs can obtain more information by consulting local hospital pharmacies or formal overseas medical consultation agencies.

Reference link: https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/212887s008lbl.pdf