How much capmatinib should be taken per day? 2 pills or 4 pills?

Capmatinib is a targeted drug targeting MET exon 14 skipping mutations (METex14) and is mainly used to treat advanced non-small cell lung cancer (NSCLC). Many patients are concerned about the correct dosage and method of taking the drug to ensure optimal therapeutic effects.

According to official recommendations, the standard dose of capmatinib is 400mg twice a day, that is, a total of 800mg taken a day. Since the drug comes in 200mg tablets, patients usually need to take 2 tablets at a time, for a total of 4 tablets a day. If the patient experiences severe side effects while taking the medication, the doctor may adjust the dose based on the patient's tolerance, for example, reducing it to 200 mg twice a day, with the total dose reduced to 400 mg. However, dosage adjustments must be made under the guidance of a doctor, and patients should not reduce the dosage or discontinue the medication without authorization, otherwise the therapeutic effect may be affected.

You also need to pay attention to how you take capmatinib. It is recommended to take it on an empty stomach, that is, 1 hour before a meal or 2 hours after a meal to ensure optimal absorption of the drug in the body. If the patient experiences gastrointestinal discomfort such as nausea, vomiting, loss of appetite, etc. while taking the medication, he or she can consult the doctor whether the medication time can be adjusted or anti-emetic measures can be taken.

In addition, if the patient forgets to take the medicine and it is more than 6 hours before the next dose, he can take it in time; but if the time is close to the next dose, he should skip it directly and do not take a double dose just to take the medicine to avoid increasing the risk of side effects. Patients taking capmatinib for a long time need to regularly review their liver and kidney functions and monitor changes in their condition to ensure the continued effectiveness of the treatment.

Reference materials:https://www.novartis.com/our-products/pipeline/capmatinib