What is the dosage, dosage and best time to take Avonib?

Ivosidenib (Ivosidenib) is an oral isocitrate dehydrogenase1 (IDH1) inhibitors, mainly used to treat patients with acute myeloid leukemia (AML) or cholangiocarcinoma who carry IDH1 mutations. When used for adult acute myeloid leukemia, the recommended dose is usually 500mg, administered orally once a day. The specific dose should be adjusted according to the patient's condition and the guidance of the doctor.

For patients with locally advanced or metastatic cholangiocarcinoma carrying IDH1 mutations, the standard dose of ivonib is also 500mg, taken once a day continuously until disease progression or intolerable toxicity occurs. During the treatment process, the patient's blood routine, liver function and electrocardiogram should be regularly monitored to ensure safety and efficacy.

Ivonib is generally recommended to be taken at a fixed time each day to maintain stable blood levels. You can choose to take it at a fixed time in the morning or evening, and can be taken with or without food. If patients experience gastrointestinal discomfort, it is recommended to take it with food to reduce adverse reactions. When taking the medicine, swallow the tablet whole and avoid crushing or chewing to ensure the sustained release properties of the medicine.

If you miss a dose, but it is more than 12 hours before the next dose, you can take it as soon as possible; if it is less than 12 hours, skip this dose and continue taking the next dose at the normal time. Do not double the dose. In addition, patients should avoid eating grapefruit or drinking grapefruit juice while taking ivonib to prevent it from affecting drug metabolism and thus affecting efficacy and safety.

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