How does filazonatant affect hormone levels?

Fezolinetant (Fezolinetant) is a new drug mainly used to treat hot flashes (hot flashes) in menopausal women. Its mechanism of action is different from traditional hormone therapy. It does not directly affect estrogen levels in women, but relieves hot flashes by regulating a nervous system mechanism in the body called the hypothalamic temperature regulation center.

Fizonatant is a non-hormonal drug that affects the temperature regulation mechanism of the hypothalamus by selectively inhibiting the action of neuropeptide Y (NPY) and neuropeptide receptor Y1. The hypothalamus is a key part of controlling body temperature. In menopausal women, due to fluctuations and decreases in hormone levels, there is an imbalance in temperature regulation, which can lead to hot flashes. Fezonatant modulates this mechanism to reduce the frequency and severity of hot flashes.

Unlike traditional hormone replacement therapies (such as estrogen or combined estrogen and progesterone therapy), fezonatant does not directly change the levels of estrogen or other sex hormones, so when used, it does not cause hormone-related side effects like hormone therapy, such as the risk of breast cancer and endometrial cancer. It has no significant effect on hormone levels in the body, making it an alternative option for women who are contraindicated by or unwilling to undergo hormone therapy.

In summary, Fezonatant reduces the occurrence of hot flashes by regulating the temperature regulatory center in the nervous system rather than directly interfering with hormone levels in the body, so it has a smaller impact on hormone levels. This makes it a safe and effective non-hormonal option for patients when treating menopausal symptoms.

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Reference materials:https://www.veozah.com/