Price trend and analysis of Osimertinib/Tagressa in 2025

Osimertinib/Tagrisso (Osimertinib) is a targeted drug targeting epidermal growth factor receptor (EGFR) kinase, mainly used in patients with non-small cell lung cancer (NSCLC). Its indications are wide. First, osimertinib is suitable for adult patients with EGFR exon 19 deletion or exon 21 L858R mutation after tumor resection as adjuvant therapy to reduce the risk of recurrence and improve survival rate.

Secondly, osimertinib is recommended as a first-line treatment for patients with metastatic non-small cell lung cancer who have EGFR exon 19 deletion or exon 21 L858R mutation. This treatment can effectively control tumor progression and improve patients' quality of life.

In addition, osimertinib can also be used in combination with pemetrexed and platinum-based chemotherapy, and is suitable for patients with locally advanced or metastaticNSCLC, providing them with a more systematic treatment option. Finally, it is also an effective treatment modality for patients with EGFR T790M mutation-positive metastatic non-small cell lung cancer, especially those whose disease has progressed after treatment with EGFR tyrosine kinase inhibitors (TKIs).

In China, the original drug of Osimertinib is already on the market. The common packaging specifications are30 tablets of 80mg and 30 tablets of 40mg. The price range is about RMB 4,000 to 6,000 yuan per box. The good news is that osimertinib has also been included in the medical insurance system, and patients can use medical insurance reimbursement to reduce drug costs, thereby reducing their personal financial burden. In overseas markets, the original drug of osimertinib is expensive, and each box may cost more than 10,000 US dollars. Fortunately, there are also generic drugs available in overseas markets, and these generic drugs are highly similar in ingredients to the original drugs. For example, the price of 80mg*30 tablets produced by pharmaceutical manufacturers in Laos and Bangladesh is only around RMB 800 (the price may change due to exchange rate fluctuations), which is very cost-effective.

Reference: https://go.drugbank.com/drugs/DB09330