How much does Selpercatinib cost per box in 2025?

Selpercatinib/Selpercatinib is a targeted therapy drug mainly used to treat non-small cell lung cancer (NSCLC), thyroid cancer and other related tumors with RET gene mutations. Its mechanism is to prevent the growth and spread of tumor cells by selectively inhibiting RET tyrosine kinase activity. The drug has a broad therapeutic range and is particularly suitable for patients with RET mutations confirmed by genetic testing. In recent years, with the development of medicine, targeted therapy has gradually become an important choice for tumor treatment.

In terms of clinical application, seputinib has shown good efficacy, especially in advanced or metastatic patients, with high objective response rate and disease control rate, providing patients with a new treatment option. In addition, seputinib is relatively well tolerated. Common adverse reactions include fatigue, dry mouth, diarrhea, etc. Most patients can tolerate it and continue to receive treatment.

Regarding price, the original drug of Seputinib is on the market in China, but it has not yet been included in the medical insurance catalog, which means that patients need to bear the relevant costs themselves. Taking the specification of 80mg*56 capsules per box as an example, the price is expected to exceed RMB 10,000. In contrast, the price of original drugs in overseas markets is relatively high, usually between 20,000 to more than 100,000 yuan. The specific price will vary due to exchange rate fluctuations.

In order to reduce the financial burden on patients, generic drugs of seputinib have also appeared overseas. These generic drugs are basically the same in ingredients as the original drugs and are relatively cheap. For example, a generic drug produced by a Lao pharmaceutical factory with a specification of 40mg*120 tablets may be sold for more than 2,000 yuan, and is still affected by exchange rate fluctuations. Although generic drugs are more affordable, patients still need to consult their doctor carefully when choosing to ensure the effectiveness and safety of the drug.

Reference materials:https://medlineplus.gov/druginfo/meds/a620036.html