How much does a box of 2025 mavacamten capsules cost?

Mavacamten is a drug specifically indicated for adults with symptomatic heart failure secondary to obstructive hypertrophic cardiomyopathy (HCM) and is indicated for patients with New York Heart Association (NYHA) Class II and III classes to improve functional capacity and symptoms. The drug was approved by the U.S. Food and Drug Administration (FDA) in 2022 based on the pivotal Phase III clinical study EXPLORER-HCM, which evaluated Mavacartide in the treatment of patients with symptomatic obstructive hypertrophic cardiomyopathy.

Mavacate acts on cardiac myosin allosterically, selectively and reversiblyATPase, thereby reducing the formation of cross-bridges between actin and myosin. This mechanism significantly reduces the probability of cross-bridge formation during systole and diastole, and excessive myosin-actin cross-bridge arrangement and relaxation state imbalance are typical features of HCM. By promoting energy conservation and a state of ultra-relaxation, Mavakate can effectively reduce left ventricular outflow tract (LVOT) obstruction and improve cardiac filling pressure, providing patients with a better quality of life.

Mavakatai’s original drug has been officially launched in the country and has been included in medical insurance. Common specifications include2.5mg*14 capsules*2 plates, 5mg*14 capsules*2 plates, 10mg*14 capsules*2 plates, and 15mg*14 capsules*2 plates, etc. Since it has not been on the market for a long time, the price has not yet been determined. There are original research versions of Mavaketai overseas, including European and American versions. The American version with 2.5mg specification is priced at approximately RMB 60,000 per box, while the European version with 5mg specification is priced at approximately RMB 20,000 per box (prices may fluctuate due to exchange rate changes). In addition, there are also imitation versions of Mavaceta in overseas markets. The ingredients of the drug are similar to the original drug, and each box sells for about 1,050 yuan (also affected by the exchange rate).

Reference materials:https://en.wikipedia.org/wiki/Mavacamten