Study on the timing of taking axitinib/axitinib: before or after meals?

Axitinib/Axitinib (Axitinib) is an oral targeted drug used to treat advanced renal cell carcinoma (RCC), mainly in patients whose disease has progressed after previous treatment. Axitinib reduces tumor blood supply by selectively inhibiting multiple tyrosine kinases, especially vascular endothelial growth factor receptor (VEGFR), thereby inhibiting tumor growth and spread. In addition, it also has a certain inhibitory effect on other related tyrosine kinases, such as PDGFR and c-KIT, allowing it to exhibit multiple mechanism effects in the treatment of renal cell carcinoma.

Clinical studies have shown that axitinib can significantly prolong progression-free survival (PFS) and overall survival (OS). In some cases, axitinib has shown promising therapeutic effects as monotherapy, while in other cases it can be used in combination with immunotherapy or chemotherapy to enhance overall efficacy. One of the great advantages of axitinib is that it continues to work despite treatment with other drugs, making it one of the important options for second-line or subsequent treatment.

As for the taking time, clinical recommendations indicate that axitinib can be taken before or after meals. Patients should maintain a certain interval when using it. It is generally recommended to take it once every 12 hours. In terms of specific operation, patients should swallow the medicine whole with a full glass of water to ensure that the medicine can smoothly enter the digestive tract and be effectively absorbed. This method of administration not only helps reduce irritation to the gastrointestinal tract, but also improves the bioavailability of the drug.

Reference materials:https://go.drugbank.com/drugs/DB06626