How much does a box of tepotinib cost?

Tepotinib (tepotinib) is an anti-cancer drug used to treat adult non-small cell lung cancer (NSCLC) , with the trade name Tepmetko, First approved for marketing in Japan in March 2020 as an "indeterminate line" drug, meaning it is approved for treatment-first patients and patients who have failed previous treatment attempts, it is the second therapy approved by the U.S. Food and Drug Administration to treat non-small cell lung cancer with these specific mutations.

Tepotinib is a highly selective inhibitor of methionine kinase activity, with an average IC50 of approximately 1.7 nmol/L. Its duration of action is moderate and it needs to be administered once a day. Tepotinib has been associated with the development of interstitial lung disease (ILD)/pneumonitis (which can sometimes be fatal). Patients should be closely monitored for new or worsening respiratory symptoms (e.g., dyspnea, cough). If ILD/pneumonitis is suspected, Tepotinib treatment should be discontinued immediately. If no other potential cause of ILD/pneumonitis is identified, treatment with tepotinib should be suspended indefinitely.

The original drug of Tepotinib is a new type of drug that is not yet on the market in China and therefore has not been included in the medical insurance. The price of Tepotinib original drug specifications225mg*30 tablets per box listed overseas is around RMB 80,000 (the price may fluctuate due to the exchange rate). It has been on the market for a short time and is expensive. There are also Tepotinib generic drugs produced in other countries. The price of 225mg*60 tablets produced by a Lao pharmaceutical factory is around RMB 8,600 per box (the price may fluctuate due to the exchange rate). The ingredients of generic drugs produced abroad are basically the same as those of the original drug. For specific prices and drug details, please consult Yaode Medical Consultant.