What is Teriflunomide?

Teriflunomide (Teriflunomide) is a pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties. This immunomodulator can reduce the number of activated central nervous system lymphocytes, thereby playing anti-inflammatory and anti-proliferative effects. Teriflunomide is commonly used to treat patients with relapsing-remitting multiple sclerosis (MS).

The exact mechanism of teriflunomide's action in multiple sclerosis is unknown. Teriflunomide is known to prevent pyrimidine synthesis by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase, which may be related to its immunomodulatory effect in multiple sclerosis. Teriflunomide is mainly hydrolyzed to minor metabolites. Other minor metabolic pathways include oxidation,N-acetylation, and sulfate conjugation. Teriflunomide is not metabolized by CYP450 or flavin monoamine oxidase. After oral administration of teriflunomide, the drug can reach maximum plasma concentration within 1-4 hours on average and can be extensively bound to plasma proteins (greater than 99%). Teriflunomide may cause teratogenic risks and is contraindicated in pregnant women or women of childbearing age.

The original drug of teriflunomide has been marketed in China and has entered the scope of medical insurance through medical insurance reimbursement standards. It may be limited to multiple sclerosis patients who have failed conventional treatments. However, the reimbursement ratio is different in different regions, and the price after reimbursement is different. Specifications The price of 14mg*28 tablets per box is around 10,000 yuan, which is expensive. Cheaper generic drugs are also sold in other overseas countries. The pharmaceutical ingredients of generic drugs are basically the same as those of the original drugs. The price of each box of 14mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 800 (the price may fluctuate due to exchange rates).