How to take Tolvaptan tablets to treat heart failure

Tolvaptan is indicated for the treatment of clinically significant hypervolemic and isovolemic hyponatremia (serum sodium <125 mEq/L or less obvious hyponatremia that is symptomatic and cannot be corrected by fluid restriction), including patients with heart failure and syndrome of inappropriate antidiuretic hormone (SIADH).

Clinical studies have shown that tolvaptan tablets did not reduce all-cause mortality, length of hospital stay, and clinical events of acute heart failure. The use of tolvaptan tablets can reduce weight, increase serum sodium levels, and improve some congestion symptoms, which can avoid the disadvantages of diuretics, especially in patients with renal insufficiency. Tolvaptan tablets may be an optional treatment for acute heart failure. The usual starting dose of tolvaptan tablets is15 mg once daily without regard to meals. After at least 24 hours, increase dose to 30 mg once daily to a maximum of 60 mg once daily to achieve desired serum sodium levels. Do not take tolvaptan tablets for more than 30 days to minimize the risk of liver damage.

Tolvaptan tablets have been marketed in China and have entered the scope of Class B medical insurance. The price paid by medical insurance is relatively cheap, but the reimbursement ratio is different in different regions, and the price after reimbursement will be different. Domestic pharmacies or hospitals will sell this drug, and the original drug of tolvaptan tablets is also on the market overseas. There are also generic tolvaptan tablets produced in other countries. The price of Indian pharmaceutical factory production specifications15mg*4 tablets per box is around RMB 800 (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs are basically the same as those of domestic and foreign original drugs.