Is Tolvaptan a diuretic?

Tolvaptan tablets (Tolvaptan) are a type of diuretic. It blocks the action of vasopressin V2 receptors and reduces renal tubular reabsorption of water, thereby increasing urine output. Tolvaptan tablets are a specific diuretic indicated for use in certain conditions, including hypervolemic and isovolemic hyponatremia, and rapidly progressive autosomal dominant polycystic kidney disease, and should be used under physician supervision.

Diuretics are a class of drugs that help reduce excess fluid load in the body by promoting the production and elimination of urine. Tolvaptan tablets selectively act on the V2 receptors in the kidneys, reducing water reabsorption, thereby increasing urine production. In people with polycystic kidney disease, many fluid-filled cysts form in the kidneys, which gradually grow and expand, putting pressure on the kidneys and eventually leading to impaired kidney function. Tolvaptan tablets have been shown to slow the growth of cysts, thereby delaying the progression of the disease. This allows tolvaptan tablets to act as a diuretic in conditions such as polycystic kidney disease that require regulating water balance.

Tolvaptan tablets have been marketed in China and have entered the scope of Class B medical insurance. The price paid by medical insurance is relatively cheap, but the reimbursement ratio is different in different regions, and the price after reimbursement will be different. Domestic pharmacies or hospitals will sell this drug, and the original drug of tolvaptan tablets is also on the market overseas. There are also generic tolvaptan tablets produced in other countries. The price of Indian pharmaceutical factory production specifications15mg*4 tablets per box is around RMB 800 (the price may fluctuate due to the exchange rate). The ingredients of foreign generic drugs are basically the same as those of domestic and foreign original drugs.