Does EIKANCE 0.01% Atropine Sulfate Eye Drops require refrigeration and the impact of storage conditions on its efficacy?

0.01% Atropine Sulfate Eye Drops (EIKANCE) is a low-concentration atropine preparation commonly used to control the progression of myopia in children. As an ophthalmic drug, its storage conditions directly affect drug stability and efficacy. Atropine is a light- and heat-sensitive compound that may break down or become ineffective under inappropriate conditions, so proper storage is critical to ensure eye drops are effective.

According to the drug instructions, 0.01%Atropine Sulfate Eye Drops are usually recommended to be stored in a cool, dry place below 25°C when unopened. Some products clearly indicate in the instructions that they can be stored refrigerated (2–8°C), especially in hot or humid environments, which can help prolong the stability of the drug. Refrigerated storage can slow down the decomposition rate of atropine, maintain the concentration of the solution and the physical and chemical properties of the eye drops, thereby ensuring the efficacy of each use.

After opening, the eye drops must be used strictly according to the instructions to avoid contamination. It is generally recommended to use it within 28 days after opening to avoid long-term storage. Even under refrigerated conditions, the stability and safety of the medicinal solution after opening may be affected by contact with air, hands or dropper contamination. When storing, avoid direct sunlight, high temperature and humid environment, and ensure that the bottle cap is sealed to prevent drug degradation or microbial growth.

Failure to store according to storage conditions may result in reduced efficacy or eye drops irritating the eyes. If the color or smell of the medicinal solution is abnormal, or the efficacy is significantly weakened after use, use should be stopped and replaced with a new medicine. In short, 0.01%Atropine Sulfate Eye Drops (EIKANCE) should follow the principles of light protection, low temperature and sealing during storage and use. Refrigeration should be considered especially in high temperature seasons to ensure efficacy and safety.

Keyword tags:

Atropine sulfate eye drops, atropine, eye drops, myopia control, storage conditions, refrigeration, efficacy stability

Reference materials:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124893/