What is the common dosage of Fenelidone/Cashenda?

Finerenone As a new mineral corticoid receptor antagonist (MRA), its common dosage usually depends on the patient's renal function level (eGFR). To ensure the safety and effectiveness of the drug, dosage adjustments are necessary, especially during the initial treatment phase and long-term maintenance phase.

1. Starting dose:

1. Patients with eGFR ≥ 60 mL/min/1.73 m²: For patients with good renal function, the recommended starting dose is 20 mg once a day. This dose is suitable for most patients, especially those with higher eGFR.

2. Patients with eGFR 25-59mL/min/1.73 m²: For patients with moderate renal function, the starting dose is 10mg once a day. These patients have relatively poor renal function and therefore require lower starting doses to avoid excessive drug accumulation and side effects.

3. Patients with eGFR<25mL/min/1.73 m²: For patients with severely impaired renal function (such as patients with end-stage renal disease), the use of fenelidone is not recommended. Because the kidneys in these patients are unable to effectively clear the drug, use of fenelidone may be associated with an increased risk of adverse effects.

2. Maintenance dose:

1. Target maintenance dose: Patients should adjust their dose based on their treatment response and serum potassium levels 4 weeks after starting treatment. For most patients, the target maintenance dose is 20 mg once daily. This dose can help patients maintain kidney function and cardiovascular health over the long term.

2. Dose adjustment: During the treatment process, monitor the patient's serum potassium level regularly and adjust the dose when necessary. Particularly in those patients with elevated potassium levels, dose reduction or temporary discontinuation may be necessary.

In general, the dose of fenelidone needs to be individually adjusted based on the patient'seGFR and serum potassium levels. During the treatment process, patients should communicate with their doctors regularly to ensure the timeliness of dose adjustment and therapeutic effect.

Keyword tags: Finerenone,Finerenone, dosage, starting dose, maintenance dose, eGFR, renal function, dose adjustment, serum potassium

Reference materials:https://pmc.ncbi.nlm.nih.gov/articles/PMC8329022/