Dosage and usage of aficamten-MYQORZO

aficamten (aficamten)-MYQORZO is indicated for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) The dosage and method of use of prescription targeted drugs have strict normative and individualized requirements. In clinical application, it is necessary to dynamically adjust the core indicators of the patient's heart function and strictly follow the medication operation specifications to maximize the treatment effect and reduce the risk of adverse reactions and heart failure.

The recommended dose of this drug adopts a stepwise ascending dosing schedule to take into account both efficacy and tolerability. The initial recommended dose is 5 mg per day, administered orally, and only needs to be taken once a day. Subsequently, based on the patient's index evaluation results (mainly based on changes in LVEF and LVOT-G values), the dose can be increased by 5 mg every 2 to 8 weeks until the maintenance dose is adjusted to suit the individual patient. It should be noted that the maximum recommended daily dose should not exceed 20 mg, and unauthorized overdose is strictly prohibited. The formulation of the maintenance dose needs to be completely individualized. The doctor will comprehensively consider the patient's cardiac function improvement, index compliance status, and medication tolerance to formulate an exclusive long-term medication dosage plan.

In terms of specific usage, Afkaita tablets are more flexible to take. They need to be taken at a fixed time every day and can be taken with food or on an empty stomach. It will not affect the absorption effect of the drug. When taking the medicine, please note that the tablet must be swallowed whole. Do not break it, chew it or grind it before taking it, so as not to damage the dosage form structure of the medicine, affect the efficacy of the medicine or increase the risk of adverse reactions.

In the case of missed doses, the principle of replenishing doses must be strictly followed to avoid the risk of excessive dose due to improper replenishment. If the patient forgets to take the medicine, he should take the corresponding dose as soon as possible on the same day after discovering the missed dose. If it is close to the scheduled medication time for the next day, there is no need to take the medicine again, and the regular dose can be taken directly at the normal scheduled time the next day. Special reminder: It is strictly forbidden to take two doses of Afkatai tablets on the same day to prevent the accumulation of the drug in the body and increase the risk of serious risks such as heart failure.

Reference materials:https://www.ema.europa.eu/en/medicines/human/EPAR/myqorzo