Effects of Trientine and its selling price

Trientine(Trientine) is a prescription drug with a clear positioning in the field of genetic metabolic diseases. It mainly focuses on the intervention of abnormal copper metabolism in the body. As the drug is gradually launched in China, more and more patients are beginning to pay attention to its therapeutic effect as well as real-life price and accessibility issues.

1. Main functions and characteristics of Trientine (Trientine)

From the perspective of pharmacological mechanism, trientine is a copper chelator drug. Its core function is not to directly improve a certain laboratory indicator, but to fundamentally control the progression of the disease by regulating the abnormal accumulation of copper in the body. Its main functions are reflected in the following aspects:

1) By combining with free copper in the body to form a stable complex, it promotes the excretion of copper through urine, thereby gradually reducing the systemic copper load;

2) Reduce further deposition of copper in the liver, brain tissue and other important organs, helping to reduce the risk of continued damage to organ function;

3) As an important alternative for patients with penicillamine intolerance, it has a relatively stable safety basis in long-term treatment;

4) It is suitable for use in the long-term maintenance treatment phase of patients with hepatolenticular degeneration to help maintain the relative balance of copper levels in the body.

Based on clinical experience, trientine is not a "quick-acting" symptomatic drug, but a basic drug that emphasizes continuous management and long-term control. Its value is more reflected in delaying disease progression, reducing the risk of recurrence, and improving long-term quality of life rather than rapid improvement in short-term symptoms.

2. The listing and supply status of Trientine at home and abroad

At present, Trientine has been officially launched in China, but due to the relatively short launch time, relevant supporting policies are still in the stage of gradual improvement. Information including medical insurance access, reimbursement ratios, coverage of designated hospitals, etc. may vary greatly in different regions. Patients usually need to refer to the information published by the local hospital pharmacy or the competent department.

In overseas markets, trientine, as a mature drug for the treatment of hepatolenticular degeneration, has formed a relatively stable supply system. Among them, the original drugs in the European market have a long history of use, and the production standards and quality control systems are relatively complete.

3. Trientine sales price and patient burden

From a price point of view, trientine is one of the drugs for special diseases with relatively high overall drug costs. The German version of the original trientine drug currently on the market overseas has a common specification of 200 mg × 100 tablets, and its single box price may exceed 40,000 yuan. The price will be affected by exchange rate fluctuations, procurement channels and local policies, so there is a certain amount of room for fluctuation.

Domestically, because Trientine has just been launched, a unified and transparent price system has not yet been formed, and whether it will be included in the medical insurance catalog and the specific reimbursement ratio still need to be further clarified. Before the medical insurance policy is fully implemented, patients' actual out-of-pocket expenses may be relatively high, which is also a practical problem faced by many families during the initial treatment.

4. Several points that patients need to pay attention to when paying attention to price

When considering the price of trientine, patients and families usually also need to consider the following aspects:

1) This drug is mostly used for long-term or even lifelong management, and the cost of medication needs to be evaluated from a long-term perspective;

2) There may be differences in the procurement channels and pricing methods of hospitals in different regions;

3) Subsequent adjustments to medical insurance policies may have a significant impact on patients’ financial burden;

4) Medication safety, stability and price are equally important, and price alone should not be used as the criterion for judgment.

Keyword tags: Trientine price,Trientine efficacy, hepatolenticular degeneration medication, copper excretion treatment, trientine marketing status, Wilson disease treatment cost

Reference materials:https://go.drugbank.com/drugs/DB06824