What is the specific usage and dosage of selumetinib/coceyu?

The dose of selumetinib for the treatment of neurofibromatosis (NF1) is calculated based on the patient's body surface area (BSA) and is usually taken orally twice daily, approximately 12 hours apart, until disease progression or unacceptable toxicity occurs. It is best to take it on an empty stomach. Avoid eating 2 hours before or 1 hour after each dose to optimize absorption.

1. Body surface area dose: There is no specific dose recommendation for patients whose body surface area is less than0.55m². Patients with BSA between 0.55-0.69m² should take 20mg orally in the morning and 10mg at night; patients with 0.70-0.89m² should take 20mg orally twice a day; patients with 0.90-1.09m² should take 25mg orally twice a day; patients with 1.10-1.29m² 30 mg twice a day for patients with 1.30-1.49 m²; 35 mg twice a day for patients with 1.30-1.49 m²; 40 mg twice a day for patients with 1.50-1.69 m²; 45 mg twice a day for patients with 1.70-1.89 m²; 50 mg twice a day for patients with 1.90 m² and above.

2. Medication precautions: During the medication period, the dosage and dosage interval must be strictly followed, and the dosage should not be increased or decreased at will. If you miss a dose, take the next dose as soon as possible and avoid increasing the dose twice in a row. When patients experience serious adverse reactions, they should adjust the dosage or suspend medication under the guidance of a doctor.

3. Combined medication and diet: Currently, it is not recommended to use it with strongCYP3A4 inhibitors to avoid increased toxicity due to increased blood concentration. Try to avoid high-fat meals or alcoholic beverages while taking the medication to reduce gastrointestinal discomfort.

4. Children and special groups: Children and adolescent patients should be strictly grouped according to BSA when calculating doses, and attention should be paid to growth and development and laboratory index monitoring. Elderly patients need to pay attention to liver and kidney function and adjust the dosage appropriately.

In short, through scientific dose management and patient education, selumetinib can achieve optimal efficacy while ensuring safety, providing long-term treatment options for patients with NF1 and other indications.

Keyword tags: Selumetinib dosage, Selumetinib usage, NF1 oral medication, body surface area dosage, NF1 treatment in children, drug absorption precautions

References:https://alexion.us/-/media/alexion_global/documents/regulatory/north-america/usa/2025/koselugo_uspi.pdf