Indications of pomalidomide

Pomalidomide (Pomalidomide), as a thalidomide analogue, has a wide range of clinical applications and is mainly used to treat multiple myeloma (MM) and some AIDS-related diseases. It improves treatment outcomes and prolongs patient survival through immunomodulatory, anti-tumor, and anti-angiogenic effects. The following are the main indications for pomalidomide:

1. Multiple myeloma (MM) treatment

Pomalidomide is used in combination with dexamethasone to treat patients with multiple myeloma who have already received at least two treatments, including lenalidomide and a proteasome inhibitor. For these patients who still show disease progression within 60 days of the last treatment, pomalidomide combined with dexamethasone is considered an effective option. This treatment regimen has been widely used in clinical practice and can effectively control disease progression and improve patient survival.

2. AIDS-related Kaposi's sarcoma (KS) treatment

In addition to multiple myeloma, pomalidomide is also used to treat AIDS-related Kaposi's sarcoma (KS). Especially in patients who have failed highly active antiretroviral therapy (HAART), pomalidomide has shown significant efficacy. In addition, pomalidomide is also used in HIV-negative patients with Kaposi's sarcoma to help inhibit tumor growth.

In summary, the multiple indications of pomalidomide make it important in anti-tumor treatment, especially for those patients who are resistant to lenalidomide, which usually show stronger efficacy. It provides patients with effective treatment options by modulating the immune system, inhibiting tumor growth, and promoting the suppression of tumor angiogenesis.

Keyword tags: pomalidomide, indications, multiple myeloma, Kaposi's sarcoma, AIDS

Reference materials:https://www.drugs.com/mtm/pomalidomide.html