Is it safe to take Tilorisen (Harcos) for half a year to maintain normal liver function? Summary of expert advice

Pitolisant (Pitolisant) is an oral H3 receptor antagonist/inverse agonist mainly used to treat narcolepsy and other sleepiness-related diseases. It blocks the H3 receptors in the central nervous system and enhances the activity of histamine neurons, thereby increasing the level of wakefulness and improving symptoms of daytime sleepiness. Compared with traditional stimulants, tilorisen is less addictive and can improve cognition and daytime alertness. It is one of the commonly used targeted drugs for patients with narcolepsy.

Clinical data shows that after a patient takes tilolixane continuously for half a year, if the liver function monitoring results are normal, it usually indicates that the drug is well tolerated. In most patients, liver enzyme levels did not change significantly during medium and long-term use, and no serious hepatotoxic events occurred. The instructions for tilolixen also emphasize that in patients with normal liver function, conventional doses are generally safe, but regular follow-up is still required to ensure early detection of potential problems.

Experts suggest that during long-term use, even if liver function is normal, blood biochemical indicators should be monitored every few months, especially ALT, AST and bilirubin levels. If mild abnormalities occur, the drug dosage and other medication conditions need to be evaluated, and the dosage adjusted or treatment suspended if necessary. At the same time, patients should pay attention to lifestyle management and avoid drinking large amounts of alcohol or taking other drugs that may increase the burden on the liver to reduce potential risks.

In general, patients who take tilorisen for half a year and have normal liver function can generally consider it safe to use, with good clinical efficacy and good tolerability. By regularly monitoring liver function, paying attention to adverse reactions, and conducting individualized dosage management as directed by your doctor, you can maximize the safety of medication and continue to improve daytime alertness and quality of life of narcolepsy patients.

Keyword tags: tilorisen, narcolepsy, liver function monitoring, long-term medication, safety

References:https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-wakix-pitolisant-treatment-daytime-sleepiness-narcolepsy