Does Seladelpar need to be taken long-term?

Seladelpar (Seladelpar) is a drug for the treatment of primary biliary cholangitis (PBC) . Its efficacy usually needs to be maintained through long-term continuous use. PBC is a chronic disease. Patients have a long course of disease, and treatment needs to be continued for a long time to effectively control the disease and delay the progression of the disease. Therefore, Siladepa's treatment regimen usually requires patients to adhere to long-term medication.

Since the mechanism of action of Siladepa is mainly through activating thePPAR-δ pathway to regulate liver lipid metabolism, reduce cholestasis, relieve inflammation and prevent liver fibrosis, it can continue to work over a long period of time. If the drug is stopped midway, it may lead to recurrence or worsening of the condition, especially in those patients who have already begun to develop liver damage and fibrosis. Therefore, for most patients, it is crucial to persist in taking Siladepa for a long time, which can help maintain the improvement of their biochemical indicators and effectively delay the deterioration of the condition.

Clinical data also show that long-term use of Siladepa can maintain the stability of patients' liver function. Especially in the treatment plan combined with ursodeoxycholic acid (UDCA), patients can achieve significant clinical improvement within a certain period of time. Although improvements in efficacy may be seen in the short term, once the medication is discontinued, the patient's liver function may quickly return to its untreated state, so long-term medication is key to avoiding disease recurrence and maintaining symptom remission.

In addition, patients need to undergo regular medical examinations during the medication period, especially monitoring of liver function, to ensure the sustainability of the drug's efficacy and to detect possible side effects in a timely manner. The doctor will adjust the treatment plan and dosage according to the patient's condition to ensure optimal drug treatment.

Keyword tags: Siladepa, long-term use, primary biliary cholangitis,PBC, PPAR-δ, treatment plan, stable liver function, maintenance of efficacy

Reference materials:https://go.drugbank.com/drugs/DB12390