How budesonide oral suspension (Eohilia) works

Budesonide oral suspension (Eohilia) is a drug widely used to treat eosinophilic esophagitis (EoE), mainly through anti-inflammatory effects to relieve patients' symptoms. Budesonide is an anti-inflammatory corticosteroid with high glucocorticoid effects and weak mineralocorticoid effects. The mechanism of action of budesonide is closely related to its affinity for the glucocorticoid receptor, which is approximately 200 times that of cortisol and 15 times that of prednisolone. This allows budesonide to exert a strong anti-inflammatory effect while maintaining low mineralocorticoid side effects when treating some immune-related inflammatory diseases.

When budesonide is used to treat eosinophilic esophagitis (EoE), it improves patient symptoms by inhibiting esophageal inflammation caused by allergic reactions. EoE is a chronic immune-mediated disease mainly caused by the accumulation and activation of eosinophils in the esophagus. Although budesonide's exact mechanism of action is not fully understood, studies have shown that it can reduce inflammation in the esophagus by reducing the activity of multiple immune cell types, such as eosinophils, mast cells, neutrophils, macrophages, and lymphocytes.

Budesonide has broad inhibitory effects on a variety of cell types and mediators involved in allergic inflammation. For example, it inhibits the release of histamines, eicosanoids, interleukins, and other cytokines, which are mediators that play a role in allergic reactions. Through this series of effects, budesonide can effectively reduce esophageal inflammation caused by EoE and relieve symptoms such as dysphagia and esophageal pain.

The high glucocorticoid effect of budesonide allows it to effectively modulate the immune system response and reduce tissue damage caused by overactivation of the immune system. Compared to other steroids, budesonide has fewer systemic side effects because its local effects are more pronounced, especially in the digestive system.

Keyword tags: budesonide,Eohilia, eosinophilic esophagitis, glucocorticoids, anti-inflammatory drugs, esophageal inflammation, immune regulation

References:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=56f2023a-69b2-4470-b4ad-af7ec1be527a