What are the contraindications for Trientine?

Trientine (Trientine), as a copper chelator, is mainly used to treat Wilson's disease (rare disease), that is, hepatolenticular degeneration. This disorder is a copper metabolism disorder caused by a genetic mutation. Patients cannot effectively eliminate excess copper ions in the body, causing copper to accumulate in the liver, brain and other organs, eventually causing serious health problems. Trientine helps patients remove copper from their bodies by binding to it, thereby reducing symptoms and preventing organ damage. However, although trientine is effective in treating Wilson's disease, it is not suitable for all patients and may have contraindications in some cases.

Contraindications to trientine include patients who are allergic to its active ingredient or any of its excipients. The active ingredient is Trientine hydrochloride, which binds to copper ions and promotes their removal from the body. For patients with known allergic reactions to Trientine or its excipients (such as fillers, capsule shell materials, etc.), the use of Trientine may lead to the occurrence of allergic reactions. Anaphylaxis may manifest as rash, shortness of breath, facial swelling, severe allergic reaction (such as anaphylactic shock), etc. In this case, the patient must stop using trientine and seek medical attention immediately.

Although trientine is primarily used to treat liver disease, in some cases it may place an additional burden on liver and kidney function. Particularly in patients with pre-existing hepatic and renal insufficiency, caution is required when using trientine. Although in some cases, doctors may choose to adjust the dose in these patients, close monitoring of liver and kidney function is required.

In summary, trientine plays an important role in the treatment ofWilson's disease, but its contraindications include allergies to the active ingredients or excipients, patients with liver and kidney dysfunction, and pregnant and lactating women. Patients should strictly follow medical instructions when using trientine and undergo regular medical monitoring to ensure that the treatment is safe and effective.

Keyword tags:

Trientine, contraindications, allergic reactions, liver and kidney function, pregnant women, lactation, drug interactions

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