Is it appropriate to take 4 tablets of Lapatinib/Talisat at one time? What should you pay attention to?

Lapatinib(Lapatinib) is an oral targeted drug that is usually used in combination with capecitabine or other drugs to treat HER2-positive metastatic breast cancer. The dose of lapatinib can vary based on the patient's condition and treatment needs. The common specifications are 0.25g per tablet and 70 tablets per bottle. Below we will answer the question about whether it is appropriate to take 4 tablets of lapatinib at one time and discuss its precautions in detail.

1. Recommended dose of lapatinib: According to the instructions for use of lapatinib, the dose is different for patients with different conditions:

1) Combined use with capecitabine: The recommended dose of lapatinib is 1250 mg (5 0.25g tablets), taken orally once a day, and the treatment cycle is 21 days. This means that patients need to take 5 tablets of lapatinib every day in combination with capecitabine to treat HER2-positive metastatic breast cancer.

2) HER2-positive and hormone receptor-positive breast cancer: If the patient is hormone receptor-positive, HER2-positive, and metastatic breast cancer, the recommended dose is 1500 mg (6 0.25g tablets), once a day.

Taking 4 tablets of lapatinib (1000 mg at one time) does not meet the recommended dosage, especially when used in combination with capecitabine. This dose may be lower than the standard therapeutic dose, affecting the therapeutic effect. Depending on the treatment plan, if the patient is underweight or has special health conditions, the doctor may adjust the dose according to the situation, but generally, it is not recommended to change the dose at will.

Lapatinib should be taken at least 1 hour before or after a meal. Because food may affect the absorption of the drug, taking it after meals may cause the drug to be less effective. To ensure the drug works best, patients are advised to take it on time and avoid taking it with a high-fat meal.

Keyword tags: lapatinib, dose, capecitabine, taking time, side effects, drug interactions

Reference materials:https://www.medicines.org.uk/emc/product/6292/smpc