What are the side effects of Bosutinib?

Bosutinib is a tyrosine kinase inhibitor widely used in the treatment of chronic myeloid leukemia (CML). Similar to other tyrosine kinase inhibitors (TKIs), although bosutinib has clinically significant anti-tumor effects, its use may also be accompanied by some side effects. Understanding these side effects can help patients stay alert during treatment and communicate with their doctors in a timely manner to optimize treatment plans.

First, the most common side effect of bosutinib is gastrointestinal symptoms. About half of patients will experience gastrointestinal discomfort such as nausea, vomiting, and diarrhea while taking bosutinib. Diarrhea is the most common side effect of bosutinib treatment and usually occurs in the early stages of treatment. Although most patients' diarrhea symptoms will be relieved as treatment continues, in some patients, diarrhea may become more severe and need to be controlled by medications or dietary adjustments.

In addition, bosutinib may cause mild liver damage. Patients should regularly monitor liver function during treatment to detect liver problems in a timely manner. Some patients may experience symptoms such as elevated liver enzymes or jaundice, especially during the initial treatment phase. Therefore, patients taking bosutinib should have regular liver function tests to ensure liver health.

In addition, bosutinib may cause hematologic side effects, including anemia, thrombocytopenia, and neutropenia. These side effects may affect the patient's immune system and blood, leading to an increased risk of infection. Therefore, patients should undergo regular blood tests during treatment to ensure that blood indicators are within the normal range.

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