Drug contraindications and usage recommendations for tenofovir alafenamide fumarate tablets (Vemlidy)

Tenofovir alafenamide fumarate tablets (Vemlidy/Vemlidy) is a drug used to treat hepatitis B virus (HBV) infection. It is one of the hepatitis B virus (HBV) nucleoside analog reverse transcriptase inhibitors (NRTI). By inhibiting the reverse transcription of HBV, it reduces virus replication, thereby helping to control viral load and alleviate liver inflammation and damage. This drug has become one of the common treatment options in the treatment of hepatitis B due to its low side effects and strong efficacy.

1. Contraindications

Although tenofovir alafenamide fumarate tablets are widely used clinically, there are still some contraindications, and patients must be cautious when using this drug. First, tenofovir alafenamide fumarate tablets are contraindicated in patients with known allergies to its ingredients. Allergic reactions may manifest as rash, difficulty breathing, facial swelling and other symptoms. Once these symptoms occur, you should stop taking the drug and seek medical advice immediately.

Secondly, patients with renal insufficiency should be particularly careful when using tenofovir alafenamide fumarate tablets, especially those with renal tubular disease or renal failure. The drug is metabolized in the kidneys, and patients with impaired renal function may cause the drug to accumulate in the body, thereby increasing the drug's toxicity and even causing kidney damage. Therefore, patients with abnormal renal function must undergo a detailed renal function assessment before starting treatment, and renal function should be monitored regularly during treatment.

2. Usage suggestions

When using tenofovir alafenamide fumarate tablets, patients should follow the doctor's prescribed dosage and ensure continued use of the drug. Generally speaking, the recommended dose for adults is 10 mg taken orally once daily. This medication is best taken after meals to reduce gastrointestinal discomfort. Patients need to undergo regular monitoring of viral load, liver function and kidney function during use to evaluate the efficacy and potential side effects of the drug.

Keyword tags:

Tenofovir alafenamide fumarate, Veride, hepatitis B, nucleoside analogs, drug contraindications, usage recommendations, renal function, drug monitoring

Reference materials:https://www.ema.europa.eu/en/documents/product-information/vemlidy-epar-product-information_en.pdf