What is the daily dosage of 20mg cabozantinib?

Cabozantinib (Cabozantinib) has a variety of dosage specifications in clinical applications. The 20mg dosage has high flexibility in actual treatment and is often used in the dosage adjustment stage or individualized treatment of specific groups of people. For indications such as renal cell carcinoma (RCC),hepatocellular carcinoma (HCC), differentiated thyroid cancer (DTC), and pancreatic neuroendocrine tumors (pNET), the cabozantinib regimen needs to be comprehensively judged based on the disease type, patient tolerance, and previous treatments.

Based on medication guidelines and research experience, cabozantinib is usually administered orally once daily. The 20mg strength does not necessarily mean “taking only one tablet a day”, but serves as an important part of the dose combination and tapering plan. In some patients, especially those who are sensitive to drugs or experience adverse reactions during treatment, doctors may adjust the total daily dose to 20 mg, 40 mg, or use 20 mg tablets for flexible combination to achieve a balance between efficacy and tolerability.

For the initial treatment stage, some cancer types may use a relatively high starting dose. However, during the treatment, if the patient experiences persistent gastrointestinal reactions, skin adverse reactions or obvious fatigue, 20mg cabozantinib is often used for maintenance treatment after dose reduction. This approach is common in overseas cancer treatment, and the purpose is to improve the sustainability of long-term medication for patients without significantly affecting the anti-tumor effect.

In terms of taking method, it is usually recommended to take cabozantinib on an empty stomach, that is, to keep a certain time interval between meals to reduce the impact of food on drug absorption. At the same time, patients should try to take medicine at a fixed time every day to avoid missing doses or increasing the dosage on their own. If you need to adjust the dose using the 20mg strength, be sure to follow the specific plan prescribed by your doctor instead of deciding the number of tablets to take daily.

Reference materials:https://www.medicines.org.uk/emc/product/15682/smpc