How effective is pomalidomide?

Pomalidomide (Pomalidomide) is an immunomodulatory drug that is a thalidomide analog and is mainly used to treat multiple myeloma (MM). It has become an important drug for the treatment of relapsed and refractory multiple myeloma by regulating the effects of the immune system and acting directly on tumor cells, inhibiting their growth and promoting apoptosis of tumor cells. Pomalidomide has shown significant therapeutic effects in multiple clinical studies when used in combination with other drugs such as bortezomib and dexamethasone.

Pomalidomide combined with bortezomib and dexamethasone is currently one of the first-line treatment strategies for multiple myeloma. The combination therapy was effective in inhibiting the progression of myeloma, relieving symptoms and extending survival in patients who had received at least one prior treatment regimen, including lenalidomide. Through combination therapy, pomalidomide can not only enhance the anti-tumor effect of the immune system, but also help patients achieve longer remissions by directly acting on myeloma cells to inhibit their proliferation.

Pomalidomide plus dexamethasone is particularly effective in patients with relapsed and refractory multiple myeloma. Such patients often have poor response to traditional treatments, and their condition relapses and is difficult to control. The use of pomalidomide, especially in combination with dexamethasone, provides a new treatment idea. Dexamethasone, a steroid drug, can help reduce inflammation and symptoms associated with myeloma, while pomalidomide improves treatment effectiveness through immunomodulatory and cytotoxic effects, especially in patients with significant disease progression.

The success of these treatment options lies in their highly effective combination therapies, which both enhance the sensitivity of myeloma cells to treatment and achieve sustained remission and disease control by improving the immune system's response. With the continuous research and development of new treatment options and drugs, the use of pomalidomide has become an important treatment option for patients with advanced multiple myeloma, helping to improve patients' quality of life and prolong survival.

Reference materials:https://www.drugs.com/mtm/pomalidomide.html