What is the difference in price comparison of generic drugs of Alpelisib?

The high price of Alpelisib - Piqray is a concern for many breast cancer patients. Original drugs are more expensive in the international market and domestically, but many overseas generic drug manufacturers have launched corresponding products, providing patients with more affordable options. The core advantage of generic drugs is that the ingredients are basically the same as the original drugs, while the price difference is significant.

For example, the generic Apelvis drug produced by Laos Lucius Pharmaceutical Factory is 150mg*28 tablets per box, and the price is about 2,000 yuan; the price of the same specification product produced by Laos United Pharmaceutical Factory is about more than 1,000 yuan. Such price differences are mainly related to production costs, exchange rate changes and supply chain management. Overseas practice shows that generic drugs, on the premise of ensuring the consistency of active ingredients, provide feasible treatment options for patients with limited financial resources, and at the same time expand the accessibility of drugs.

In terms of efficacy, overseas regulatory agencies usually require generic drugs to be consistent with the original drugs in terms of quality, content and bioequivalence. Therefore, the clinical effects and safety of generic drugs obtained through formal channels are basically equivalent to those of original drugs. For patients, choosing generic drugs can not only reduce the economic burden, but also improve compliance during long-term treatment, allowing the targeted treatment plan to be continued.

It should be noted that when using generic drugs, patients should pay attention to the reliability of the source and ensure that the drugs meet the standards of the Food and Drug Administration. Purchasing uncertified medicines from informal channels may lead to risks of unstable quality or differences in ingredients, affecting treatment efficacy and safety.

Overall, generic Apelvis drugs have more price advantages than the original drugs and can achieve similar curative effects in clinical applications, providing patients with diversified choices. As the international drug supply system gradually improves, the emergence of generic drugs has significantly improved the accessibility of targeted treatments and also provided an economically feasible solution for the long-term treatment of breast cancer and other potential indications in the future.

Reference materials:https://www.ncbi.nlm.nih.gov/books/NBK574353/